Fig. 1 · Structure
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LY 303511 dihydrochloride
K+ Current Inhibitor
LY 303511 dihydrochloride is a selective K+ current inhibitor that enhances TRAIL sensitivity in SHEP-1 neuroblastoma cells. Unlike its analogue LY294002, this compound does not inhibit PI3K activity. In MIN6 insulinoma cells, LY 303511 dihydrochloride reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM, making it a valuable tool for research into cellular excitability and apoptosis mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 854127-90-5 |
| Applications | K+ Current Inhibitor |
| Formula | C19H20Cl2N2O2 |
| Molecular Weight | 379.28 |
| SMILES | O=C1C=C(N2CCNCC2)OC3=C(C4=CC=CC=C4)C=CC=C31.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.