LY 345899

Catalog No.: A19440

MTHFD1/MTHFD2 inhibitor

LY 345899

LY 345899 Chemical Structure

CAS NO. 10538-99-5

LY 345899 is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 0.018 μM.

Availability: In stock

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5 mg

Regular Price: $405.00

Special Price $324.00

10 mg

Regular Price: $690.00

Special Price $552.00

50 mg

Regular Price: $2,050.00

Special Price $1,640.00

100 mg

Regular Price: $3,000.00

Special Price $2,400.00

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Biological Activity

LY 345899 is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 0.018 μM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.06 mL 212.13 mL
0.5 mM 4.24 mL 21.21 mL 42.43 mL
1 mM 2.12 mL 10.61 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19440
Actions Inhibitor
CAS No. 10538-99-5
Formula C20H21N7O7
M. Wt 471.42
Purity >98%
Synonyms LY345899; LY-345899
SMILES O=C(O)[[email protected]@H](NC(C1=CC=C(N2C(N3C4=C(NC(N)=NC4=O)NCC3C2)=O)C=C1)=O)CCC(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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