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LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
Targets
| Rat neurons expressing native mGlu2/3 | Recombinant human mGlu3 | Recombinant human mGlu2 | ||
| 88 nM(Ki) | 92 nM(Ki) | 149 nM(Ki) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.52 mL | 212.59 mL | 425.17 mL |
| 0.5 mM | 8.5 mL | 42.52 mL | 85.03 mL |
| 1 mM | 4.25 mL | 21.26 mL | 42.52 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.5 mL |
*The above data is based on the productmolecular weight 235.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10544 |
|---|---|
| Actions | Agonist |
| M. Wt | 235.2 |
| Formula | C7H9NO6S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 635318-11-5 |
| Synonyms | LY-404039, LY-2140023 |
| SMILES | C1[[email protected]]([[email protected]@H]2[[email protected]]([[email protected]@H]2S1(=O)=O)C(=O)O)(C(=O)O)N |
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