Fig. 1 · Structure
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LY2389575 hydrochloride
mGlu3 NAM
LY2389575 hydrochloride is a selective noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 190 nM. This compound enhances Mrc1 levels while independently intensifying Amyloid beta (Aβ) toxicity. It serves as a valuable tool for investigations related to Alzheimer's disease and the underlying mechanisms of neurodegeneration.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 885104-09-6 |
| Applications | mGlu3 NAM |
| Formula | C15H16BrCl3N4 |
| Molecular Weight | 438.58 |
| SMILES | ClC1=CC=C(CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2)C(Cl)=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.