LY2389575 hydrochloride is a selective noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 190 nM. This compound enhances Mrc1 levels while independently intensifying Amyloid beta (Aβ) toxicity. It serves as a valuable tool for investigations related to Alzheimer's disease and the underlying mechanisms of neurodegeneration.
LY2389575 hydrochloride is a selective noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3), exhibiting an IC50 value of 190 nM. This compound enhances Mrc1 levels while independently intensifying Amyloid beta (Aβ) toxicity. It serves as a valuable tool for investigations related to Alzheimer's disease and the underlying mechanisms of neurodegeneration.
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