Documents & Downloads

LY243246

De novo Purine synthesis Inhibitor

LY243246 is a selective inhibitor of de novo purine synthesis, acting as a competitive antagonist of 5'-phosphoribosylglycinamide formyltransferase (GAR transformylase). As the 6S diastereomer of DDATHF, it exhibits potent inhibitory effects similar to its 6R counterpart, making it a valuable tool for investigating the regulation of purine metabolism. This compound is instrumental in studies related to cellular proliferation and potential therapeutic applications in diseases involving aberrant purine synthesis.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	106400-18-4
Applications	De novo Purine synthesis Inhibitor
Formula	C₂₁H₂₅N₅O₆
Molecular Weight	443.45
Synonyms	(6S)-DDATHF
SMILES	O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CC[C@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.