Fig. 1 · Structure
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LY2457546
Anticancer Agent
LY2457546 is a potent, orally active inhibitor of multiple tyrosine kinases, primarily targeting VEGFR2, PDGFRβ, FLT-3, Tie-2, and various Eph receptors. This compound exhibits significant anti-angiogenic activity, making it a valuable tool for cancer research, particularly in the study of leukemia. Its capacity to interfere with tumor vascularization and growth highlights its potential in developing targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 908265-94-1 |
| Applications | Anticancer Agent |
| Formula | C28H20F4N4O |
| Molecular Weight | 504.48 |
| SMILES | O=C(CC1=CC=C(C2=CN=C3C=C(C4=CC(C)=NC=C4)C=CN32)C=C1F)NC5=CC=CC(C(F)(F)F)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.