Fig. 1 · Structure
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LY266097 hydrochloride
5-HT2B Antagonist
LY266097 hydrochloride is a selective antagonist of the 5-HT2B receptor, with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively. The blockade of the 5-HT2B receptor by LY266097 is significant for investigating pathways associated with depression and other neuropsychiatric disorders. This compound provides valuable insights into serotonergic signaling and may aid in the development of therapeutic strategies targeting these receptors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 172895-39-5 |
| Applications | 5-HT2B Antagonist |
| Formula | C21H24Cl2N2O2 |
| Molecular Weight | 407.33 |
| SMILES | CC1=CC2=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.