LY2835219 (abemaciclib)

Catalog No.: A12989

CDK4/6 inhibitor

LY2835219 (abemaciclib)

LY2835219 (abemaciclib) Chemical Structure

CAS NO. 1231929-97-7

LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

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Package Price Qty
5 mg
$60.00
10 mg
$90.00
50 mg
$110.00
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  • Hidemasa Matsuo, .et al. Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia, Blood Adv, 2018, Nov 13; 2(21): 2879-2889 PMID: 30381403
  • Iriyama N, .et al. The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells, Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692

Biological Activity

LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.7 mL 197.4 mL
0.5 mM 3.95 mL 19.74 mL 39.48 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12989
Actions Inhibitor
M. Wt 506.59
Formula C27H32F2N8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1231929-97-7
Synonyms LY 2835219, LY-2835219
SMILES CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F

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