LY2934747 is a selective dual agonist for the mGlu2 and mGlu3 receptors, demonstrating blood-brain barrier permeability. With Ki values of 260 nM and 177 nM and EC50 values of 8.4 nM and 62.4 nM for human receptors, it effectively mediates signaling pathways associated with these targets. LY2934747 displays antipsychotic and analgesic activities in vivo, making it a valuable tool for research into psychosis and pain management.
LY2934747 is a selective dual agonist for the mGlu2 and mGlu3 receptors, demonstrating blood-brain barrier permeability. With Ki values of 260 nM and 177 nM and EC50 values of 8.4 nM and 62.4 nM for human receptors, it effectively mediates signaling pathways associated with these targets. LY2934747 displays antipsychotic and analgesic activities in vivo, making it a valuable tool for research into psychosis and pain management.
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