Fig. 1 · Structure
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LY2934747
mGlu2/mGlu3 Receptor Agonist
LY2934747 is a selective dual agonist for the mGlu2 and mGlu3 receptors, demonstrating blood-brain barrier permeability. With Ki values of 260 nM and 177 nM and EC50 values of 8.4 nM and 62.4 nM for human receptors, it effectively mediates signaling pathways associated with these targets. LY2934747 displays antipsychotic and analgesic activities in vivo, making it a valuable tool for research into psychosis and pain management.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1448707-43-4 |
| Applications | mGlu2/mGlu3 Receptor Agonist |
| Formula | C10H13NO4 |
| Molecular Weight | 211.22 |
| SMILES | C(O)(=O)[C@H]1[C@@]2(C3(C[C@](C(O)=O)(N)[C@@]21[H])CC3)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.