LY2940094 tartrate is a potent and selective antagonist of the nociceptin/orphanin FQ (NOP) receptor, characterized by a high binding affinity (Ki=0.105 nM) and effective antagonistic potency (Kb=0.166 nM). This compound exhibits significant brain penetration and is orally bioavailable, making it suitable for in vivo studies. LY2940094 tartrate has demonstrated efficacy in reducing ethanol self-administration and seeking behaviors in animal models, providing valuable insights for research in addiction and neuropharmacology.
LY2940094 tartrate is a potent and selective antagonist of the nociceptin/orphanin FQ (NOP) receptor, characterized by a high binding affinity (Ki=0.105 nM) and effective antagonistic potency (Kb=0.166 nM). This compound exhibits significant brain penetration and is orally bioavailable, making it suitable for in vivo studies. LY2940094 tartrate has demonstrated efficacy in reducing ethanol self-administration and seeking behaviors in animal models, providing valuable insights for research in addiction and neuropharmacology.
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