LY3020371 is a highly selective antagonist of the metabotropic glutamate receptors 2 and 3 (mGluR2/3), exhibiting inhibition constants (Kis) of 5.26 nM and 2.50 nM for human mGluR2 and mGluR3, respectively. This compound is primarily utilized in research focused on understanding the pathophysiology of depression and exploring potential therapeutic interventions. Its potent activity against these targets makes it a valuable tool for studying the glutamatergic system in neurological disorders.
LY3020371 is a highly selective antagonist of the metabotropic glutamate receptors 2 and 3 (mGluR2/3), exhibiting inhibition constants (Kis) of 5.26 nM and 2.50 nM for human mGluR2 and mGluR3, respectively. This compound is primarily utilized in research focused on understanding the pathophysiology of depression and exploring potential therapeutic interventions. Its potent activity against these targets makes it a valuable tool for studying the glutamatergic system in neurological disorders.
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