Fig. 1 · Structure
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LY3154207
D1 Receptor PAM
LY3154207 is a highly selective positive allosteric modulator (PAM) of the human dopamine D1 receptor, demonstrating potent activity with an EC50 of 3 nM. This compound has been designed for oral bioavailability and exhibits minimal allosteric agonist activity. Its primary applications include studies of dopaminergic signaling and potential therapeutic interventions in neurological disorders related to dopamine dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1638667-79-4 |
| Applications | D1 Receptor PAM |
| Formula | C24H29Cl2NO3 |
| Molecular Weight | 450.40 |
| SMILES | O=C(N1[C@@H](C)C2=C(C(CCC(C)(O)C)=CC=C2)C[C@@H]1CO)CC3=C(Cl)C=CC=C3Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.