Fig. 1 · Structure
Documents & Downloads
LY3177833 monhydrate
CDC7 Inhibitor
LY3177833 monhydrate is a potent CDC7 inhibitor, demonstrating an IC50 of 3.3 nM, alongside its activity against pMCM2 with an IC50 of 290 nM. This compound is recognized for its ability to induce cellular senescence, making it a valuable tool in cancer research and studies related to cell cycle regulation. Its oral bioavailability enhances its applicability in in vivo studies, facilitating the exploration of CDC7-targeted therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1627696-53-0 |
| Applications | CDC7 Inhibitor |
| Formula | C16H14FN5O2 |
| Molecular Weight | 327.31 |
| SMILES | O=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3.[H]O[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.