Fig. 1 · Structure

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LY334370 hydrochloride

5-HT1F Receptor Agonist

LY334370 hydrochloride is a highly selective agonist of the 5-HT1F receptor, demonstrating a binding affinity with a Kd value of 0.446 nM. This compound exhibits noteworthy anti-migraine activity, making it valuable for research in migraine pathophysiology and treatment exploration. Its mechanism of action highlights the therapeutic potential of targeting the serotonergic system in neurological disorders.

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Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 199673-74-0
Applications 5-HT1F Receptor Agonist
Formula C21H23ClFN3O
Molecular Weight 387.88
SMILES
O=C(C1=CC=C(C=C1)F)NC2=CC3=C(NC=C3C4CCN(CC4)C)C=C2.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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