Fig. 1 · Structure
Documents & Downloads
LY3522348
KHK Inhibitor
LY3522348 is a ketohexokinase (KHK) inhibitor that targets the enzyme’s role in fructose metabolism. By inhibiting KHK, it has potential applications in studying metabolic disorders such as nonalcoholic steatohepatitis (NASH), diabetes, kidney disease, and heart failure. KHK plays a pivotal role in the phosphorylation of fructose to fructose-1-phosphate (FIP), influencing pathways that lead to lipogenesis, gluconeogenesis, and increased oxidative phosphorylation.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2568608-48-8 |
| Applications | KHK Inhibitor |
| Formula | C18H22F3N7O |
| Molecular Weight | 409.41 |
| Synonyms | KHK-IN-3 |
| SMILES | C[C@@H]1N(CC1)C2=NC(C(F)(F)F)=CC(C3=CN(N=C3)CC(N4CCNCC4)=O)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.