(±)-LY367385 is a potent and selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). It inhibits quisqualate-induced phosphoinositide hydrolysis with an IC50 value of 8.8 μM, demonstrating significant selectivity over mGluR5a, which has an IC50 greater than 100 μM. This compound is utilized in research applications focused on neuronal signaling and the modulation of excitatory neurotransmission in neurological studies.
(±)-LY367385 is a potent and selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). It inhibits quisqualate-induced phosphoinositide hydrolysis with an IC50 value of 8.8 μM, demonstrating significant selectivity over mGluR5a, which has an IC50 greater than 100 μM. This compound is utilized in research applications focused on neuronal signaling and the modulation of excitatory neurotransmission in neurological studies.
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