Fig. 1 · Structure
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LY456066
mGluR1 Antagonist
LY456066 is a selective non-competitive antagonist of metabotropic glutamate receptor 1 (mGluR1), exhibiting an IC50 of 52.0 nM. This compound demonstrates significant biological activity in rodent models, effectively reducing hyperalgesia and the pain-related behaviors of licking and flinching in response to formalin injection. LY456066 holds promise for investigating potential analgesic treatments in chronic pain research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 338738-66-2 |
| Applications | mGluR1 Antagonist |
| Formula | C19H23N3OS |
| Molecular Weight | 341.47 |
| SMILES | OCCSC1=NC(NC2CC3=C(C2)C=CC=C3)=C4CCCCC4=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.