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LY459477

mGluR2/3 Agonist

LY459477 is a selective and orally active agonist of metabotropic glutamate receptors 2 and 3 (mGluR2/3). It demonstrates significant effectiveness in suppressing locomotor activity induced by phencyclidine without impairing neuromuscular coordination. This compound serves as a valuable tool for investigating neurological diseases and the role of glutamate signaling in related therapeutic contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	635318-20-6
Applications	mGluR2/3 Agonist
Formula	C₈H₁₀FNO₄
Molecular Weight	203.17
SMILES	OC([C@]1([C@@]2([H])[C@]([C@@H](C1)F)([H])[C@@H]2C(O)=O)N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.