LY459477 is a selective and orally active agonist of metabotropic glutamate receptors 2 and 3 (mGluR2/3). It demonstrates significant effectiveness in suppressing locomotor activity induced by phencyclidine without impairing neuromuscular coordination. This compound serves as a valuable tool for investigating neurological diseases and the role of glutamate signaling in related therapeutic contexts.
LY459477 is a selective and orally active agonist of metabotropic glutamate receptors 2 and 3 (mGluR2/3). It demonstrates significant effectiveness in suppressing locomotor activity induced by phencyclidine without impairing neuromuscular coordination. This compound serves as a valuable tool for investigating neurological diseases and the role of glutamate signaling in related therapeutic contexts.
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