LYG-409

Name: LYG-409
Brand: Adooq Bioscience
SKU: A24461
Rating: 5 (288 reviews)

Catalog No.: A24461

GSPT1 degrader

LYG-409 is an orally active degrader of GSPT1 that demonstrates potent antitumor activity in vivo, with tumor growth inhibition (TGI) rates of 94.34% in acute myeloid leukemia and 104.49% in prostate cancer models. In vitro, LYG-409 inhibits KG-1 cells through GSPT1 degradation, with an IC₅₀ of 9.50 nM and a DC₅₀ of 7.87 nM.

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Grouped product items
Size	Price	Stock
5mg	$144.00	In stock
10mg	$248.00	In stock
50mg	$736.00	In stock
100mg	$1,440.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	LYG-409 is an orally active degrader of GSPT1 that demonstrates potent antitumor activity in vivo, with tumor growth inhibition (TGI) rates of 94.34% in acute myeloid leukemia and 104.49% in prostate cancer models. In vitro, LYG-409 inhibits KG-1 cells through GSPT1 degradation, with an IC₅₀ of 9.50 nM and a DC₅₀ of 7.87 nM.

Product Information

Catalog Num	A24461
Formula	C25H20F3N3O6
Molecular Weight	515.44
CAS Number	3053857-55-6
SMILES	O=C1N(CC2=C1C=CC(CNC(C3=CC4=C(OC3)C=CC(OC(F)(F)F)=C4)=O)=C2)C5CCC(NC5=O)=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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