Fig. 1 · Structure
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Lys(CO-C3-p-I-Ph)-OMe
PK Modifier
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic (PK) modifier designed to enhance the pharmacokinetic properties of PSMA ligand molecules, including Ac-PSMA-trillium. By increasing the binding affinity to albumin, this compound extends the residence time of Ac-PSMA-trillium in circulation and minimizes salivary gland uptake, thereby potentially prolonging its half-life. Ac-PSMA-trillium can serve various biological roles when modified with different radioactive isotopes; for instance, when labeled with 111In, it functions as a DOTA chelating agent for imaging, or when coupled with 225Ac, it acts as a Macropa chelator for targeted radionuclide therapy in researching metastatic castration-resistant prostate cancer (mCRPC).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2088426-96-2 |
| Applications | PK Modifier |
| Formula | C17H25IN2O3 |
| Molecular Weight | 432.30 |
| SMILES | IC1=CC=C(CCCC(NCCCC[C@@H](C(OC)=O)N)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.