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M-1111

Rapa-Link Inhibitor

M-1111 is a Rapa-Link inhibitor that covalently binds to mTOR, specifically targeting its active site. It exhibits potent inhibitory activity on the mTORC1 signaling pathway, evidenced by the suppression of phosphorylated S6 and 4E-BP1. Notably, M-1111 effectively inhibits 4E-BP1 without affecting pAkt S473 levels. This compound is invaluable for research applications related to various cancers, including liver, kidney, and colorectal cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1887095-86-4
Applications	Rapa-Link Inhibitor
Formula	C₈₉H₁₃₄N₁₂O₂₃
Molecular Weight	1740.08
SMILES	O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCOCC5=CN(CCOCCOCCOCCOCCOCCOCCOCCNC(CCCCN6C7=C(C(N)=NC=N7)C(C8=CC(N=C(N)O9)=C9C=C8)=N6)=O)N=N5)CC4)OC)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.