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M-525

Epigenetic Reader Domain Inhibitor

M-525 is a potent, irreversible inhibitor of the menin-MLL protein-protein interaction, targeting the epigenetic reader domain. With an IC50 of 3 nM, M-525 effectively inhibits cell growth and suppresses MLL-regulated gene expression in MLL leukemia cells, demonstrating significant anti-leukemia activity. This compound is valuable for research into the therapeutic mechanisms of epigenetic modulation in hematological malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2173582-08-4
Applications	Epigenetic Reader Domain Inhibitor
Formula	C₃₉H₅₁FN₆O₅S
Molecular Weight	734.92
SMILES	O=C(OC)N[C@@H]1[C@@H]([C@](C2CCN(CC3CN(C4=CC=C(S(=O)(C5CN(C(/C=C/CN(C)C)=O)C5)=O)C=C4)C3)CC2)(C#N)C6=CC=CC(F)=C6)CCC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.