Fig. 1 · Structure
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m-APTA
Chemoprotective Agent
m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent that targets methylthioadenosine phosphorylase (MTAP). By facilitating the conversion into adenine, m-APTA plays a critical role in safeguarding normal cells from the cytotoxic effects of nucleobase analogues (NBA). This compound holds potential for advancing research into MTAP-deficient cancers, offering insights into therapeutic strategies and cellular protection mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 86072-47-1 |
| Applications | Chemoprotective Agent |
| Formula | C16H18N6O3S |
| Molecular Weight | 374.42 |
| Synonyms | 5′-S-(3-Aminophenyl)-5′-thioadenosine |
| SMILES | NC1=CC=CC(SC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=NC(C3=NC=N4)=C4N)O2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.