m-Chlorophenylbiguanide (mCPBG) is a high-affinity agonist of the 5-HT3 receptor, known to inhibit long-term potentiation (LTP) in the mossy fiber-CA3 circuit. It effectively reduces the magnitude of LTP at concentrations ranging from 0.3 to 1 µM, highlighting its significant role in the modulation of synaptic plasticity. Furthermore, the reversible nature of mCPBG's effect on LTP in the presence of the GABAA receptor antagonist bicuculline suggests its involvement in GABAergic neurotransmission pathways.
m-Chlorophenylbiguanide (mCPBG) is a high-affinity agonist of the 5-HT3 receptor, known to inhibit long-term potentiation (LTP) in the mossy fiber-CA3 circuit. It effectively reduces the magnitude of LTP at concentrations ranging from 0.3 to 1 µM, highlighting its significant role in the modulation of synaptic plasticity. Furthermore, the reversible nature of mCPBG's effect on LTP in the presence of the GABAA receptor antagonist bicuculline suggests its involvement in GABAergic neurotransmission pathways.
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