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m3227G(5)ppp(5')Am

mRNA Modification

m3227G(5)ppp(5')Am is an mRNA modification featuring a 3227-methylguanine cap, a triphosphate moiety, and a 2'-O-methyladenosine. This modification, located at the first coding nucleotide adjacent to the 5' cap, plays a crucial role in enhancing mRNA stability and regulating translational efficiency. It is valuable for studies focused on mRNA metabolism, stability, and gene expression regulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	178422-14-5
Applications	mRNA Modification
Formula	C₂₄H₃₅N₁₀O₁₇P₃
Molecular Weight	828.51
SMILES	O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](OC)[C@@H]4O)(O)=O)(O)=O)([O-])=O)O3)C=[N+]2C)NC(N(C)C)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.