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M3686

TEAD1/TEAD3 Inhibitor

M3686 is a selective inhibitor of TEAD1, exhibiting an IC50 value of 51 nM, with weaker binding to TEAD3. This compound significantly reduces cell viability in YAP-dependent NCI-H226 cell lines, demonstrating an IC50 value of 0.06 µM. Additionally, M3686 displays robust anti-tumor effects in the NCI-H226 xenograft model, making it a valuable tool for research in cancer biology and therapeutics targeting the Hippo pathway.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2738550-24-6
Applications	TEAD1/TEAD3 Inhibitor
Formula	C₂₁H₁₈F₃N₅O₂
Molecular Weight	429.40
SMILES	O[C@@H]1CN(C(C2=CC3=C(N(C4=CC=C(C(F)(F)F)C=C4)C5=NN(C)N=C53)C=C2)=O)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.