Fig. 1 · Structure
Documents & Downloads
M6766
ERO1α Inhibitor
M6766 is a selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α), exhibiting an IC50 of 1.4 μM and a KD of 1.1 μM. In addition, M6766 demonstrates inhibitory activity against ERO1β with an IC50 of 7.2 μM. This compound targets the flavin adenine dinucleotide-binding pocket of ERO1α, leading to effects on granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. M6766 is valuable for research involving neurological disorders, particularly ischemic stroke.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 696628-90-7 |
| Applications | ERO1α Inhibitor |
| Formula | C19H16N6S |
| Molecular Weight | 360.44 |
| SMILES | CN1C(SC2=C3CCCCC3=C(C4=NC5=CC=CC=C5N42)C#N)=NN=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.