Fig. 1 · Structure
Documents & Downloads
MAC-545496
GraR Inhibitor
MAC-545496 is a potent nanomolar inhibitor of the glycopeptide-resistance-associated protein R (GraR), exhibiting strong binding affinity with a Kd of ≤ 0.1 nM. This compound functions as an antivirulence agent, effectively reversing β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) strains. MAC-545496 is a valuable tool for research focused on combating antibiotic resistance and enhancing the efficacy of β-lactam antibiotics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 838810-96-1 |
| Applications | GraR Inhibitor |
| Formula | C18H18ClN5O3S |
| Molecular Weight | 419.89 |
| SMILES | O=C(NC(NC1=NC=C(Cl)C=C1)=S)C2=CC=C(N3CCCCC3)C([N+]([O-])=O)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.