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Magnocurarine chloride

Neuromuscular Junction Blocker

Magnocurarine chloride is a selective neuromuscular junction blocker that inhibits muscle contraction by interfering with neurotransmission at the motor end plate. It exhibits a dose-dependent paralytic effect in various animal models, including frogs, mice, and rabbits, leading to symptoms from limb weakness to severe respiratory and cardiac effects. Notably, while high doses lead to complete immobility, the spinal multineuronal reflex remains intact in frog models. Magnocurarine chloride's biological activity parallels that of tubocurarine, making it valuable for research applications in pharmacology and neurobiology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Blocker
CAS Number	75413-87-5
Applications	Neuromuscular Junction Blocker
Formula	C₁₉H₂₄ClNO₃
Molecular Weight	349.85
SMILES	COC(C=C(CC[N+]1(C)C)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3O.[Cl-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.