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Biological Activity
MAK-683 is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity.
| In vitro | DMSO | 20 mg/mL (53.13 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.57 mL | 132.84 mL | 265.68 mL |
| 0.5 mM | 5.31 mL | 26.57 mL | 53.14 mL |
| 1 mM | 2.66 mL | 13.28 mL | 26.57 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.31 mL |
*The above data is based on the productmolecular weight 376.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16922 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1951408-58-4 |
| Formula | C20H17FN6O |
| M. Wt | 376.39 |
| Purity | >98% |
| Synonyms | MAK683, MAK 683 |
| SMILES | CC1=NC=CC=C1C2=CN=C(NCC3=C(F)C=CC4=C3CCO4)N5C2=NN=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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