MAK683 hydrochloride

Catalog No.: A26730
EED Inhibitor
MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), targeting the EED protein to disrupt its function. It demonstrates potent inhibitory activity with IC50 values of 59 nM, 89 nM, and 26 nM in EED Alphascreen binding, LC-MS, and ELISA assays, respectively. This compound is primarily utilized in research applications investigating EED's role in gene regulation and cancer biology.
Grouped product items
Size Price Stock Qty
1mg
$155.00
In stock
5mg
$360.00
In stock
10mg
$550.00
In stock
25mg
$835.00
In stock
50mg
$1,175.00
In stock
100mg
$1,545.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), targeting the EED protein to disrupt its function. It demonstrates potent inhibitory activity with IC50 values of 59 nM, 89 nM, and 26 nM in EED Alphascreen binding, LC-MS, and ELISA assays, respectively. This compound is primarily utilized in research applications investigating EED's role in gene regulation and cancer biology.
Product Information
Catalog NumA26730
FormulaC20H18ClFN6O
Molecular Weight412.85
CAS Number2170606-94-5
SMILESCC1=NC=CC=C1C2=CN=C(NCC3=C4CCOC4=CC=C3F)N5C2=NN=C5.Cl
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