Fig. 1 · Structure
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MAK683 hydrochloride
EED Inhibitor
MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), targeting the EED protein to disrupt its function. It demonstrates potent inhibitory activity with IC50 values of 59 nM, 89 nM, and 26 nM in EED Alphascreen binding, LC-MS, and ELISA assays, respectively. This compound is primarily utilized in research applications investigating EED's role in gene regulation and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2170606-94-5 |
| Applications | EED Inhibitor |
| Formula | C20H18ClFN6O |
| Molecular Weight | 412.85 |
| SMILES | CC1=NC=CC=C1C2=CN=C(NCC3=C4CCOC4=CC=C3F)N5C2=NN=C5.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.