Fig. 1 · Structure
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Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan
Drug-Linker Conjugate
Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound combines Exatecan, an anthracycline derivative, with a PEG-based linker, facilitating targeted delivery of cytotoxic agents to cancer cells. It is suitable for the synthesis of ADCs and plays a vital role in cancer research, enabling the study of tumor targeting and therapeutic efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1599439-54-9 |
| Applications | Drug-Linker Conjugate |
| Formula | C57H65FN10O15 |
| Molecular Weight | 1149.18 |
| SMILES | O=C(C=CC1=O)N1CCC(NCCOCCOCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.