Fig. 1 · Structure
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MAP3K14-IN-1
MAP3K14 Inhibitor
MAP3K14-IN-1 is a potent inhibitor of MAP3K14 (NIK kinase) with an IC50 of 1.8 nM. This compound effectively inhibits the autophosphorylation of MAP3K14 kinase, leading to a decreased level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 demonstrates significant efficacy in inhibiting the proliferation of multiple myeloma cells, making it a valuable tool for research focused on multiple myeloma and related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2113617-02-8 |
| Applications | MAP3K14 Inhibitor |
| Formula | C29H31N7O2 |
| Molecular Weight | 509.61 |
| SMILES | C(O)[C@]1(C)C=2C(=C(C#N)C=C(C2)C3=NC(NC4=CC(C#N)=C(CCN5CCOCC5)C=C4C)=NC=C3)NC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.