Fig. 1 · Structure
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Maralixibat chloride
IBAT Inhibitor
Maralixibat chloride is a potent ileal bile acid transporter (IBAT) inhibitor. It demonstrates key biological activity in the modulation of bile acid metabolism, making it a valuable tool for research into rare cholestatic liver diseases, including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC), and biliary atresia. This compound is suitable for in vitro and in vivo studies aimed at understanding the pathophysiology of these conditions and evaluating potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 228113-66-4 |
| Applications | IBAT Inhibitor |
| Formula | C40H56ClN3O4S |
| Molecular Weight | 710.41 |
| Synonyms | SHP625 chloride; LUM001 chloride; Lopixibat chloride |
| SMILES | O=S1(CC(CCCC)(CCCC)[C@H](O)[C@H](C2=CC=C(OCC3=CC=C(C[N+]4(CC5)CCN5CC4)C=C3)C=C2)C6=CC(N(C)C)=CC=C61)=O.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.