Fig. 1 · Structure
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Marcfortine A
Nematode
Marcfortine A is an indole alkaloid that targets nematodes, demonstrating potent nematocidal activity against the parasitic nematode Haemonchus contortus with an LD99 of 0.06 μg/mL. It effectively inhibits the motility of adult worms, with an EC50 of 2 μM, and has been shown to eliminate multiple species, including Toxocara colubriformis and Ostertagia ostertagi, from experimentally infected jirds. In addition, Marcfortine A dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing human nicotinic acetylcholine receptors, providing valuable insights for research in neuromuscular signaling and parasitic infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 75731-43-0 |
| Applications | Nematode |
| Formula | C28H35N3O4 |
| Molecular Weight | 477.60 |
| Synonyms | NSC 324645 |
| SMILES | CN1[C@]23[C@](C[C@]4(N(CCCC4)C3)C1=O)([H])C(C)([C@@]5(C6=CC=C(OC(C)(C)C=CO7)C7=C6NC5=O)C2)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.