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Masitinib (AB1010)

c-Kit inhibitor

Masitinib (AB1010) is a protein tyrosine kinase inhibitor.

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Biological Activity

Target & Activity

Target	Activity	Value
Kit	IC50	200nM
LynB	IC50	510nM
PDGFRα	IC50	540nM
PDGFRβ	IC50	800nM
Abl1	IC50	1.20μM
c-Fms	IC50	1.48μM
Src	IC50	1.87μM
Hck	IC50	2.0μM
FLT3	IC50	>10μM
VEGFR1	IC50	>10μM
VEGFR2	IC50	>10μM
EGFR	IC50	>10μM
FGFR1	IC50	>10μM
FGFR3	IC50	>10μM
IGF-1R	IC50	>10μM
c-Met	IC50	>10μM
c-Ret	IC50	>10μM
JAK2	IC50	>10μM
BTK	IC50	>10μM
Bmx	IC50	>10μM
Syk	IC50	>10μM
Fes	IC50	>10μM
PKCα	IC50	>10μM
Pim1	IC50	>10μM
Akt1	IC50	>10μM

25 targets · Scroll to view more

Cellular Effect

Cell Line	Activity	Value	Description	Reference
BMMC	IC50	0.1 μM	Antiproliferative activity against BALB/c mouse BMMC after 48 hrs by MTT assay	[PMID: 30078608]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	790299-79-5
Applications	c-Kit inhibitor
Formula	C₂₈H₃₀N₆OS
Molecular Weight	498.6
Synonyms	Masivet; AB1010
SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	91 mg/mL (182.49 mM)
Water	Insoluble
Ethanol	4 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration: 28 mg/mL
Vehicle: 4% DMSO+30% PEG 300+5% Tween 80+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

1 publication citing this product

S Masson ,etc. Inhibition of Cell Signalling in Neoplastic Canine Mast Cells. , 2014, .