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MAT2A-IN-13

MAT2A Inhibitor

MAT2A-IN-13 is a selective inhibitor of methionine adenosyltransferase 2A (MAT2A), demonstrating significant oral bioavailability. This compound exhibits robust in vivo efficacy in the HCT-116 MTAP-deleted xenograft model, making it suitable for investigating the therapeutic potential within MTAP-deleted tumors. Its pharmacokinetic profile supports its application in various cancer research studies targeting MAT2A pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2851449-24-4
Applications	MAT2A Inhibitor
Formula	C₁₇H₁₂F₄N₄O
Molecular Weight	364.30
SMILES	O=C1C(C2=CC=CN=C2F)=C(C=C(C(F)(F)F)C=C3)N3C(NC4CC4)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.