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MAT2A-IN-20

MAT2A Inhibitor

MAT2A-IN-20 is a selective inhibitor of methionine adenosyltransferase 2A (MAT2A), demonstrating an IC50 of less than 50 nM. This compound also inhibits human UGT1A1 with an IC50 of 28.45 µM. MAT2A-IN-20 has shown promising antitumor activity in mouse models, making it a valuable tool for cancer research and investigations into metabolic pathways involving methionine metabolism.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3018834-98-2
Applications	MAT2A Inhibitor
Formula	C₂₆H₂₄F₂N₆O₄
Molecular Weight	522.50
SMILES	O=C1C(C2=CC3=C(N=C(C(C)(C)O)N3C)C=C2)=NC4=C(N1C5=CC=C(C=C5)OC(F)F)N=C(OCC)N=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.