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MAT2A-IN-23

MAT2A Inhibitor

MAT2A-IN-23 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A), exhibiting an IC50 of 4 nM. This compound effectively inhibits S-adenosylmethionine (SAM) production in both HCT-116 (MTAP−/−) and wild-type cell lines, with IC50 values of 3 nM and 2 nM, respectively. Furthermore, MAT2A-IN-23 demonstrates selective inhibition of symmetric dimethylarginine (SDMA) in HCT-116 (MTAP−/−) cells, with an IC50 of 2 nM, while displaying minimal activity in wild-type cells. In cellular assays, it significantly reduces proliferation in HCT-116 (MTAP−/−) cells with an IC50 of 47 nM, making it a valuable tool for studying MAT2A-related biological processes and potential therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2925324-58-7
Applications	MAT2A Inhibitor
Formula	C₁₉H₁₄D₃F₂N₃O
Molecular Weight	344.37
SMILES	O=C1[C@]2(C3=CC(C(F)(C)F)=CC=C3C(NC([2H])([2H])[2H])=N1)C4=CC=CN=C4CC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.