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MAT2A-IN-24

MAT2a Inhibitor

MAT2A-IN-24 is a potent inhibitor of methionine adenosyltransferase 2a (MAT2a), demonstrating an IC50 of 20 nM for enzyme inhibition. It exhibits significant antiproliferative activity against HAP1MTAP–/– cells, with an IC50 of 10 nM. This compound is valuable for research focused on tumorigenesis related to MTAP deficiency and offers a promising avenue for therapeutic exploration in relevant cancer models.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3031093-57-6
Applications	MAT2a Inhibitor
Formula	C₃₂H₃₃Cl₂N₇O₂
Molecular Weight	618.56
SMILES	CN(C)C(C1=C(N2C3=CC=CC(N4CCC(CN5C(C=C(Cl)C=C6)=C6C(N(C)C)=NC5=O)CC4)=C3)C=C(Cl)C=C1)=NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.