Fig. 1 · Structure
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MAT2A-IN-7
MAT2A Inhibitor
MAT2A-IN-7 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). Elevated expression of MAT2A has been associated with various tumors, including gastric, colon, liver, and pancreatic cancers. This compound effectively reduces the proliferative activity of cancer cells lacking the MTAP gene, making it a valuable tool for cancer research and therapeutic development. MAT2A-IN-7 offers insights into the metabolic dependencies of tumors, particularly in the context of MAT2A overexpression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2756458-77-0 |
| Applications | MAT2A Inhibitor |
| Formula | C17H13ClF3N3O2 |
| Molecular Weight | 383.75 |
| SMILES | O=C1N(C2=CC=CC=C2Cl)C3=C(C=CC(C(F)(F)F)=N3)C(NC)=C1OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.