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Mavrilimumab

Mavrilimumab (CAM 3001) is a monoclonal antibody designed to target and bind specifically to the α subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor. By attaching to this subunit, Mavrilimumab effectively inhibits the downstream intracellular signaling pathways activated by GM-CSF. This interaction is crucial, as GM-CSF is implicated as a potential mediator in the exacerbation of inflammatory responses that can lead to respiratory failure and mortality. This antibody is particularly relevant in research focused on inflammatory diseases and immune response regulation.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 1085337-57-0
Molecular Weight 145500
Synonyms CAM 3001

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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