Fig. 1 · Structure
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MB-0223
Drp1 Partial Inhibitor
MB-0223 is a selective partial inhibitor targeting the dynamin-related GTPase Drp1, with an IC50 of 1.3 μM, demonstrating high potency and specificity over other dynamin family members, such as Opa1 and dynamin-1 (IC50 > 100 μM). This compound is useful in studies investigating mitochondrial dynamics, apoptosis, and cellular energy metabolism, making it an important tool for research on neurodegenerative diseases and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2247732-89-2 |
| Applications | Drp1 Partial Inhibitor |
| Formula | C26H27N5OS |
| Molecular Weight | 457.59 |
| SMILES | O=C(C1=CC(C)=CN1CC2=CSC(N3CCCCC3)=N2)NC4=CC=C(C5=CC=CN=C5)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.