MBM-55S is a highly selective inhibitor of NIMA-related kinase 2 (Nek2) with an IC50 of 1 nM, demonstrating potency against this target. It exhibits significant selectivity for most kinases, with minor activity against RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). The compound effectively inhibits cancer cell proliferation by inducing cell cycle arrest and apoptosis, displaying notable antitumor activity without apparent toxicity in murine models. This makes MBM-55S a valuable tool for cancer research and therapeutic development.
MBM-55S is a highly selective inhibitor of NIMA-related kinase 2 (Nek2) with an IC50 of 1 nM, demonstrating potency against this target. It exhibits significant selectivity for most kinases, with minor activity against RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). The compound effectively inhibits cancer cell proliferation by inducing cell cycle arrest and apoptosis, displaying notable antitumor activity without apparent toxicity in murine models. This makes MBM-55S a valuable tool for cancer research and therapeutic development.
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