Fig. 1 · Structure
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MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
Camptothecin Payload
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin is a camptothecin payload designed for conjugation to monoclonal antibodies, facilitating the development of camptothecin antibody-drug conjugates (ADCs). This compound exhibits potent cytotoxic activity by inhibiting topoisomerase I, making it a valuable tool in targeted cancer therapy research. Its applications include investigations into the efficacy and safety of ADCs in the treatment of various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2414594-29-7 |
| Applications | Camptothecin Payload |
| Formula | C44H51FN8O12 |
| Molecular Weight | 902.92 |
| SMILES | O=C(C=CC1=O)N1CCCCCC(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(NCOCC(NCC2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C=C62)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.