Fig. 1 · Structure
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MC-Gly-Gly-Phe-Gly-GABA-Exatecan
Drug-Linker Conjugate
MC-Gly-Gly-Phe-Gly-GABA-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features Exatecan, a topoisomerase inhibitor with an IC50 of 22 μM, enabling targeted delivery of cytotoxic agents. MC-Gly-Gly-Phe-Gly-GABA-Exatecan demonstrates significant antitumor efficacy and cytotoxic activity in both in vitro and in vivo models, making it a valuable tool for cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1599439-52-7 |
| Applications | Drug-Linker Conjugate |
| Formula | C53H58FN9O12 |
| Molecular Weight | 1032.08 |
| SMILES | O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.