Fig. 1 · Structure
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MC-Val-Cit-PAB-Exatecan
Drug-Linker Conjugate
MC-Val-Cit-PAB-Exatecan is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound comprises the DNA topoisomerase I inhibitor DX-8951, which exerts cytotoxic effects by interfering with DNA replication and transcription. The inclusion of a cathepsin-cleavable linker allows for selective release of the cytotoxic payload within target cells, enhancing therapeutic efficacy in cancer research applications. This reagent serves as a valuable tool for the development and optimization of ADCs in preclinical studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2504068-28-2 |
| Applications | Drug-Linker Conjugate |
| Formula | C53H60FN9O12 |
| Molecular Weight | 1034.10 |
| Synonyms | MC-Val-Cit-PAB-DX8951 |
| SMILES | O=C(OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN(C2=O)C(C=C2)=O)=O)=O)=O)N[C@@H]3C(C4=C5CC3)=C(CN6C7=CC([C@@]8(O)CC)=C(COC8=O)C6=O)C7=NC4=CC(F)=C5C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.