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MDL-100240

Angiotensin-converting Enzyme (ACE) Inhibitor

MDL-100240 is a dual-acting angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitor. It exhibits significant antihypertensive effects, lowering blood pressure and reversing left ventricular hypertrophy while preventing aortic hypertrophy and dilatation in resistance arteries. Additionally, MDL-100240 reduces aldosterone levels and enhances bradykinin effects, making it useful in cardiovascular research. In transgenic rat models, it has been shown to diminish adrenomedullin concentrations and mitigate hypertension-induced cardiovascular damage.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	142695-08-7
Applications	Angiotensin-converting Enzyme (ACE) Inhibitor
Formula	C₂₆H₂₈N₂O₅S
Molecular Weight	480.58
SMILES	O=C(O)[C@@H]1CCC[C@@]([H])(N1C2=O)C3=CC=CC=C3C[C@@H]2NC([C@H](CC4=CC=CC=C4)SC(C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.