Fig. 1 · Structure
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MDL 101146
Neutrophil Elastase Inhibitor
MDL 101146 is a potent orally active inhibitor of neutrophil elastase, with a Ki value of 25 nM. This compound effectively suppresses neutrophil elastase activity, making it suitable for investigating inflammatory conditions such as arthritis. Its ability to modulate proteolytic enzymes offers valuable insights into therapeutic strategies for diseases characterized by excessive elastase activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 149859-17-6 |
| Applications | Neutrophil Elastase Inhibitor |
| Formula | C29H37F5N4O6 |
| Molecular Weight | 632.62 |
| SMILES | O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.