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MDL-27531

Glycine Agonist

MDL-27531 is a glycine agonist that exhibits selective inhibition of hindlimb contractions and effectively reverses strychnine-induced seizures in murine models. It has been shown to inhibit seizures induced by pentylenetetrazol, with an effective dose (ED50) of 55 mg/kg. MDL-27531 enhances the binding of the benzodiazepine antagonist Ro 15-1788 to the cerebral cortex without altering GABA levels. This compound is valuable for research involving reflex control dysfunction and seizure management.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	116850-44-3
Applications	Glycine Agonist
Formula	C₁₀H₁₁N₃O₂S
Molecular Weight	237.28
SMILES	O=S(=O)(C1=NN=C(C=2C=CC=CC2)N1C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.